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003			0001
008			180524s2010 enka b 001 0 eng
010			_a 2009033763
015			_aGBA882708 _2bnb
016	7		_a101513262 _2DNLM
016	7		_a014656398 _2Uk
020			_a9780470059852 (hardback)
035			_a(OCoLC)ocn432240645
040			_aDNLM/DLC _cDLC _dBTCTA _dNLM _dYDXCP _dBWKUK _dUKM _dOCLCA _dDLC
042			_apcc
082	0	0	_a615.19012 _222
084			_a615.19012 _bJUL-I
100	1		_aJulious, Steven A.
245	1	3	_aAn introduction to statistics in early phase trials / _h[Book] _cSteven A. Julious, Say Beng Tan, David Machin.
260			_aHoboken, NJ : _aHoboken, NJ : _bWiley-Blackwell, _c2010.
300			_a263 p. : _bill. ; _c26 cm.
365			_a01 _b0.00
520			_aAll new medicines and devices undergo early phase trials to assess, interpret and better understand their efficacy, tolerability and safety. An Introduction to Statistics in Early Phase Trials describes the practical design and analysis of these important early phase clinical trials and provides the crucial statistical basis for their interpretation. It clearly and concisely provides an overview of the most common types of trials undertaken in early phase clinical research and explains the different methodologies used. The impact of statistical technologies on clinical development and the statistical and methodological basis for making clinical and investment decisions are also explained. •Conveys key ideas in a concise manner understandable by non-statisticians •Explains how to optimise designs in a constrained or fixed resource setting •Discusses decision making criteria at the end of Phase II trials •Highlights practical day-to-day issues and reporting of early phase trials An Introduction to Statistics in Early Phase Trials is an essential guide for all researchers working in early phase clinical trial development, from clinical pharmacologists and pharmacokineticists through to clinical investigators and medical statisticians. It is also a valuable reference for teachers and students of pharmaceutical medicine learning about the design and analysis of clinical trials.
521			_aAll.
650		0	_aDrugs _xTesting _xStatistical methods.
650		0	_aClinical trials _xStatistical methods.
650	1	2	_aClinical Trials, Phase I as Topic _xmethods.
650	2	2	_aBiometry _xmethods.
650	2	2	_aClinical Trials, Phase II as Topic _xmethods.
650	2	2	_aModels, Statistical.
650	2	2	_aStatistics as Topic _xmethods.
700	1		_aMachin, David, _d1939-
700	1		_aTan, Say Beng.
852			_p58268 _96481.08 _h615.19012 JUL-I _vParadise Books International _bGround Floor _dBooks _t1 _q1-New _aJZL-CUI
999			_c64834 _d64834