Metabonomics : [Book] methods and protocols / edited by Jacob T. Bjerrum, Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.

Includes bibliographic references and index.

Metabonomics : analytical techniques and associated chemometrics / Jacob T. Bjerrum -- Sample collection and preparation of biofluids and extracts for NMR spectroscopy / Gwenaelle Le Gall -- NMR sprectroscopy of biofluids and extracts / Gwenaelle Le Gall -- High-resolution magic-angle-spinning NMR spectroscopy of intact tissue / Guro F. Giskedegard, Maria D. Cao, and Tone F. Bathen -- Sample collection and preparation of biofluids and extracts for liquid chromatography-mass spectrometry / Peiyuan Yin [and three others] -- Liquid chromatography-mass spectrometry of biofluids and extracts / Xinjie Zhao [and three others] -- Sample collection and preparation of biofluids and extracts for gas chromatography-mass spectrometry / Abdul-Hamid M. Emwas, Zeyad A. Al-Talla, and Najeh M. Kharbatia -- Gas chromatography-mass spectrometry of biofluids and extracts / Abdul-Hamid M. Emwas [and three others] -- Capillary electrophoresis-mass spectrometry / Masataka Wakayama, Akiyoshi Hirayama, and Tomoyosji Soga -- Preprocessing of raw metabonomic data / Riyas Vettukattil -- Extracting meaningful information from metabonomic data using multivariate statistics / Max Bylesjo -- Combining metabonomics and other -omics data / Mattias Rantalainen -- The strengths and weaknesses of NMR-spectroscopy and mass spectrometry with particular focus on metabolomics research / Abdul-Hamid M. Emwas -- Metabonomics and drug development / Pranov Ramana [and three others] -- Metabonomics and toxicology / Liang Zhao and Thomas Hartung -- Metabonomics and diagnostics / Lucy C. Hicks, Simon J.L. Ralphs, and Horace R.T. Williams -- Metabonomics and systems biology / Vicky De Preter.

This volume on metabonomics provides detailed information on the procedures involved in nuclear magnetic resonance (NMR) spectroscopy, gas chromatography-mass spectrometry (GS-MS), liquid chromatography-mass spectrometry (LC-MS), and capillary electrophoresis-mass spectrometry (CE-MS). Chapters focus on technologies and chemometrics, generation of metabonomics data, extraction of meaningful information from data, drug development, toxicology, diagnostics, and describing metabonomics as an essential part of systems biology. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

All.